Selective COX-2 Inhibitors 124 Forthispurpose

Forthispurpose

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Selective COX-2 Inhibitors 124 ForthispurposeThe mainstay of therapy for rheumatoid disease is the non steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with